Aspirin crosses the blood-brain barrier in acidic blood.Aspirin may lead to hypoglycemia and/or low CNS glucose availability: monitor blood glucose concentrations and administer dextrose as warranted.Aspirin poisoning often leads to dehydration: administer intravenous fluids as necessary to restore and maintain intravascular volume.Monitor serial serum drug levels, and carefully consider the potential benefit of activated charcoal administration or whole bowel irrigation. After overdose, aspirin may be absorbed from the gut into the bloodstream over a prolonged period of time.Principles of medical management of aspirin poisoning Aspirin poisoning is best cared for by clinicians with appropriate knowledge and experience in treating critical drug poisoning. The following information is also available as a downloadable PDF.Īspirin can be deadly in overdose! Healthcare providers are encouraged to attend to aspirin poisoning cases with the same diligence afforded to cases of sepsis or other life-threatening diseases.

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